A proposed sustainability index for synthesis plans based on input provenance and output fate: application to academic and industrial synthesis plans for vanillin as a case study

• John Andraos

Beilstein J. Org. Chem. 2020, 16, 2346–2362, doi:10.3762/bjoc.16.196

• and the fate of output waste products. The index is computed as the root-mean-square average of the following four parameters: mass fraction of valorized inputs (FVI), mass fraction of valorized outputs (FVO), mass fraction of valorized target product (FVP), and input enthalpic energy fraction arising

• ) consumption, input enthalpic energy (IEE) consumption, Rowan solvent greenness index (RSGI), and sustainability index (SI). Keywords: Borda count; green chemistry; input enthalpic energy; process mass intensity; poset dominance analysis; Rowan solvent greenness index; sacrificial reagent; sustainability

• mass fractions defined in Equations 5–7, we can define an analogous input enthalpic energy fraction arising from renewable energy sources (FRE) as shown in Equation 10. This definition is similar to renewability index proposed earlier [15]. In the present formalism we define the following energy